Dynamic Cardiomyoplasty: Insights into the Mechanisms of its Success
نویسندگان
چکیده
Dynamic cardiomyoplasty is a recently developed operation for the treatment of end-stage heart failure. Recent studies have focused on the potential mechanism by which it may work. We have shown in a canine model of heart failure, using transformed muscle, that CMP has at least two mechanisms. First, it stabilizes ventricular function and volumes chronically by a girdling mechanism. Secondly, dynamic assistance acts acutely to augment systolic contraction. These two mechanisms act to stabilize cardiac function and may potentially allow for reversal of the chronic remodeling process seen with progressive heart failure.
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تاریخ انتشار 2007